ATAGI advises that the Pfizer bivalent BA.4/5 vaccine can be used as a booster dose by adolescents and adults aged ≥12 years who are recommended to receive a COVID-19 booster according to the ATAGI 2023 booster advice. The Pfizer bivalent BA.4/5 vaccine is not currently registered for use in children aged <12 years or as a primary series .. Immunogenicity and safety of a bivalent (omicron BA.5 plus ancestral) SARS-CoV-2 recombinant spike protein vaccine as a heterologous booster dose: interim analysis of a phase 3, non-inferiority, randomised, clinical trial. A bivalent omicron-containing booster vaccine against Covid-19. N Engl J Med. 2022; 387: 1279-1291. View in Article.
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The research cohorts included 3,368,697 adults vaccinated with the fourth dose, of which 1,290,999 were bivalent BA.4-5-vaccinated, 992,282 were bivalent BA.1-vaccinated, and 1,085,416 were.. Pfizer-BioNTech Comirnaty ® Original and Omicron BA.4/BA.5, bivalent COVID-19 vaccine. The Pfizer-BioNTech Comirnaty ® Original and Omicron BA.4/BA.5, bivalent COVID-19 vaccine is approved as a primary series for people who are 6 months of age and older and as a booster for people who are 5 years of age and older. Its safety and effectiveness.
